| Date | Location | Result | |
| Nov 19, 2010 | Morehead, Ky. | Morehead State 3, Murray State 1 (25-21,23-25,25-21,25-21) | Box score |
| Nov 18, 2010 | Morehead, Ky. | Murray State 3, Eastern Kentucky 1 (25-21,19-25,25-23,26-24) | Box score |
| Nov 13, 2010 | Murray, Ky. | Morehead State 3, Murray State 0 (29-27,25-9,25-23) | Box score |
| Nov 12, 2010 | Murray, Ky. | Murray State 3, Eastern Kentucky 0 (25-15,25-21,25-15) | Box score |
| Nov 6, 2010 | Jacksonville, Ala. | Jacksonville State 3, Murray State 1 (22-25,25-15,25-22,26-24) | Box score |
| Nov 5, 2010 | Cookeville, Tenn. | Tennessee Tech 3, Murray State 2 (20-25,25-14,21-25,29-27,15-13) | Box score |
| Nov 2, 2010 | Murray, Ky. | Murray State 3, UT Martin 1 (25-21,24-26,25-23,27-25) | Box score |
| Oct 28, 2010 | Edwardsville, Ill. | Murray State 3, SIU Edwardsville 2 (27-29,17-25,25-21,25-22,15-8) | Box score |
| Oct 26, 2010 | Cape Girardeau, Mo. | Murray State 3, Southeast Missouri 1 (19-25,25-19,25-18,27-25) | Box score |
| Oct 23, 2010 | Murray, Ky. | Austin Peay 3, Murray State 2 (18-25,25-17,25-20,16-25,15-13) | Box score |
| Oct 22, 2010 | Murray, Ky. | Murray State 3, Tennessee State 0 (27-25,27-25,25-12) | Box score |
| Oct 16, 2010 | Murray, Ky. | Murray State 3, Eastern Illinois 0 (25-23,25-15,25-19) | Box score |
| Oct 15, 2010 | Murray, Ky. | Murray State 3, Southeast Missouri 1 (25-22,21-25,25-19,25-21) | Box score |
| Oct 9, 2010 | Richmond, Ky. | Eastern Kentucky 3, Murray State 0 (27-25,25-18,25-22) | Box score |
| Oct 8, 2010 | Morehead, Ky. | Morehead State 3, Murray State 0 (25-16,25-20,25-20) | Box score |
| Oct 2, 2010 | Murray, Ky. | Murray State 3, Tennessee Tech 2 (22-25,25-21,29-27,16-25,15-9) | Box score |
| Oct 1, 2010 | Murray, Ky. | Jacksonville State 3, Murray State 2 (25-20,25-23,16-25,13-25,15-12) | Box score |
| Sep 28, 2010 | Charleston, Ill. | Eastern Illinois 3, Murray State 1 (25-22,18-25,25-23,25-20) | Box score |
| Sep 25, 2010 | Murray, Ky. | Murray State 3, SIU Edwardsville 0 (25-20,25-15,25-15) | Box score |
| Sep 22, 2010 | Martin, Tenn. | Murray State 3, UT Martin 1 (25-10,20-25,25-18,25-20) | Box score |
| Sep 18, 2010 | Nashville, Tenn. | Murray State 3, Tennessee State 1 (29-27,25-27,25-18,25-16) | Box score |
| Sep 17, 2010 | Clarksville, TN | Austin Peay 3, Murray State 1 (27-25,25-13,23-25,25-22) | Box score |
| Sep 1, 2010 | Evansville, Ind. | Evansville 3, Murray State 0 (25-15,26-24,25-17) | Box score |
| Sep 11, 2010 | Evansville, Ind. | Murray State 3, Western Carolina 0 (25-19,25-14,25-22) | Box score |
| Sep 10, 2010 | Evansville, Ind. | Loyola 3, Murray State 2 (25-20,23-25,25-22,21-25,15-12) | Box score |
| Sep 4, 2010 | Cincinnati, Ohio | Cincinnati 3, Murray State 0 (25-17,25-15,25-19) | Box score |
| Sep 4, 2010 | Cincinnati, OH | Murray State 3, Kent State 2 (25-22,14-25,26-24,20-25,15-11) | Box score |
| Sep 2, 2010 | Cincinnati, Ohio | Murray State 3, James Madison 0 (25-23,25-19,25-18) | Box score |
| Aug 28, 2010 | Laramie, Wyo. | Wyoming Cowgirls 3, Murray State 1 (25-20,27-29,25-21,25-20) | Box score |
| Aug 28, 2010 | Laramie, Wyo. | Central Arkansas 3, Murray State 0 (26-24,25-23,25-21) | Box score |
| Aug 27, 2010 | Laramie, Wyo. | Northern Arizona 3, Murray State 1 (25-22,25-18,23-25,25-18) | Box score |
| Aug 27, 2010 | Laramie, Wyo. | Southern Utah 3, Murray State 0 (25-22,25-14,25-23) | Box score |