| Date | Location | Result | |
| 03/04/21 | Evansville, Ind. (Ford Center) | Jacksonville St. 68, Murray St. 65 | Box score |
| 02/27/21 | Cookeville, Tenn. (Eblen Center) | Tennessee Tech 71, Murray St. 61 | Box score |
| 02/25/21 | Jacksonville, Ala. (Mathews Coliseum) | Jacksonville St. 87, Murray St. 74 | Box score |
| 02/20/21 | Murray, Ky. (CFSB Center) | Murray St. 89, SIUE 62 | Box score |
| 02/18/21 | Murray, KY | Eastern Ill. 68, Murray St. 59 | Box score |
| 02/15/21 | Edwardsville, Ill. (1st Community Arena) | Murray St. 86, SIUE 57 | Box score |
| 02/13/21 | Murray, Ky. (CFSB Center) | Murray St. 84, UT Martin 55 | Box score |
| 02/12/21 | Murray, Ky. (CFSB Center) | Murray St. 80, Southeast Mo. St. 60 | Box score |
| 02/06/21 | Richmond, Ky. (McBrayer Arena) | Murray St. 76, Eastern Ky. 64 | Box score |
| 02/04/21 | Morehead, Ky. (Johnson Arena) | Morehead State 66, Murray St. 56 | Box score |
| 02/01/21 | Cape Girardeau, Mo. (Show Me Center) | Murray St. 77, Southeast Mo. St. 60 | Box score |
| 01/30/21 | Murray, Ky. (CFSB Center) | Belmont 72, Murray St. 71 | Box score |
| 01/28/21 | Murray, Ky. (CFSB Center) | Murray St. 73, Tennessee St. 53 | Box score |
| 01/23/21 | Murray, Ky. (CFSB Center) | Murray St. 72, Tennessee Tech 63 | Box score |
| 01/21/21 | Murray, Ky. (CFSB Center) | Jacksonville St. 85, Murray St. 82 | Box score |
| 01/16/21 | Martin, Tenn. (Elam Center) | Murray St. 79, UT Martin 57 | Box score |
| 01-07-21 | Charleston, Ill. (Lantz Arena) | Eastern Ill. 74, Murray St. 68 | Box score |
| 01-02-21 | Murray, Ky. (CFSB Center) | Morehead St. 61, Murray St. 56 | Box score |
| 12-30-20 | Nashville, Tenn. (Curb Event Center) | Belmont 68, Murray St. 55 | Box score |
| 12-21-20 | Clarksville, Tenn. (Dunn Center) | Austin Peay 74, Murray St. 70 | Box score |
| 12-15-20 | Murray, KY. (CFSB Center) | Murray St. 90, Transylvania 49 | Box score |
| 12-11-20 | Carbondale, Ill. (Banterra Center) | Southern Ill. 70, Murray St. 66 | Box score |
| 12-08-20 | Murray, KY. (CFSB Center) | Murray St. 87, Austin Peay 57 | Box score |
| 12-05-20 | Murray, KY. (CFSB Center) | Murray St. 76, Illinois St. 65 | Box score |
| 12-02-20 | Murfreesboro, Tenn. (Murphy Center) | Middle Tenn. 78, Murray St. 61 | Box score |
| 11-29-20 | Murray, Ky. (CFSB Center) | Murray St. 173, Greenville 95 | Box score |